Review Article | Published: 05 January 2023

Plant secondary metabolites as an alternative to combat antimicrobial resistance: An overview of medicinal plants of Pir Panjal Himalayas

Shreekar Pant, Mohammad Vikas Ashraf, Ali Asghar Shah and Shoeb Ahmad

Journal of Non-Timber Forest Products | Volume: 29 | Issue: 3 | Page No. 121-134 | 2022
DOI: https://doi.org/10.54207/bsmps2000-2023-2I082B | Cite this article

Abstract

Antibiotics have made formidable benefactions to human civilization and found extensive usage in infectious disease treatment. However, indiscriminate and overuse of antibiotics have evolved resistant bacterial strains, which is a cause of concern to healthcare set-ups all around the world. This situation has necessitated the need of introducing new antimicrobials or combination therapies. The slow development of novel synthetic antibiotics has diverted the research towards naturally occurring antimicrobial molecules. Plant secondary metabolites, being diverse and distributed across different habitats, provide fair chances for the exploration and discovery of novel antimicrobials, mainly due to the huge reservoir of phytochemicals produced like alkaloids, flavonoids, tannins and phenolic compounds. The North-Western Himalaya fosters great diversity of medicinal plants, which present a lucrative bioresource available to be explored for the development of novel antimicrobials or potentiating molecules in combination therapies. This review presents an overview of plant-based antimicrobials reported in recent years, along with their targets and mode of action and provides an appraisal of medicinal plant resource of Pir Panjal Himalayan region, along with their reported antimicrobial phytochemicals, which provides excellent opportunity for further exploration and discovery of novel antimicrobials.

Keywords

Antimicrobials, Medicinal plants, North-western Himalayas, Phytochemicals, Plant-based inhibitors

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How to cite

Pant, S., Ashraf, M.V., Shah, A.A. and Ahmad, S., 2022. Plant secondary metabolites as an alternative to combat antimicrobial resistance: An overview of medicinal plants of Pir Panjal Himalayas. Journal of Non-Timber Forest Products, 29(3), pp.121-134. https://doi.org/10.54207/bsmps2000-2023-2I082B

Publication History

Manuscript Received on 04 December 2022

Manuscript Revised on 28 December 2022

Manuscript Accepted on 03 January 2023

Manuscript Published on 05 January 2023

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